1040264-48-9

Upstream product

• 1146162-38-0 5-hydroxy-4-methoxy-2-nitrobenzoic acid ethyl ester 
• 57616-74-7 N-(3-chloropropyl)morpholine hydrochloride 
• 1040264-46-7 ethyl 4-methoxy-3-(3-morpholin-4-ylpropoxy)benzoate 

Downstream Products

• 1040264-49-0 ethyl 2-amino-4-methoxy-5-(3-morpholin-4-ylpropoxy)benzoate 

Relevant academic research and scientific papers

A PROCESS FOR THE PREPARATION OF GEFITINIB

The present invention provides an improved, industrial advantageous process for the preparation of gefitinib of formula (I), and its pharmaceutically acceptable salts thereof in high yield and purity.

A novel synthesis of EGFR-tyrosine-kinase inhibitors with 4-(indol-3-yl)quinazoline structure

(Chemical Equation Presented) The epidermal growth factor (EGF) family of membrane receptors has been identified as a key element in the complex signaling network that is utilized by various classes of cell-surface receptors. A new synthetic pathway of 4-(indol-3-yl)quinazolines 15 and 16 is described using cross coupling reactions with quinazoline- and indole moieties. The synthesized compound 15 is a new dual and high potent EGFR- and HER-2-tyrosine kinase inhibitor with excellent cytotoxic properties at different cell lines. Furthermore this substance class shows remarkably strong fluorescence.