1040384-99-3Relevant academic research and scientific papers
SAR-oriented discovery of peroxisome proliferator-activated receptor pan agonist with a 4-adamantylphenyl group as a hydrophobic tail
Kasuga, Jun-ichi,Yamasaki, Daisuke,Ogura, Kiyoshi,Shimizu, Motomu,Sato, Mayumi,Makishima, Makoto,Doi, Takefumi,Hashimoto, Yuichi,Miyachi, Hiroyuki
, p. 1110 - 1115 (2008/09/19)
3-(4-Alkoxyphenyl)propanoic acid derivatives were prepared as candidate peroxisome proliferator-activated receptor (PPAR) α/δ/γ pan agonists, based on our previous SAR studies directed toward the development of subtype-selective PPAR agonists. Those studi
Improvement of the transactivation activity of phenylpropanoic acid-type peroxisome proliferator-activated receptor pan agonists: Effect of introduction of fluorine at the linker part
Kasuga, Jun-ichi,Oyama, Takuji,Hirakawa, Yuko,Makishima, Makoto,Morikawa, Kosuke,Hashimoto, Yuichi,Miyachi, Hiroyuki
scheme or table, p. 4525 - 4528 (2009/04/08)
We developed a potent peroxisome proliferator-activated receptor pan agonist (a candidate drug for treatment of altered metabolic homeostasis) by introducing fluorine atoms at appropriate position(s) of the known phenylpropionic acid-type pan agonist TIPP
