1040390-00-8Relevant articles and documents
A highly stereoselective synthesis of chiral α-amino-β-lactams via the Kinugasa reaction employing ynamides
Zhang, Xuejun,Hsung, Richard P.,Li, Hongyan,Zhang, Yu,Johnson, Whitney L.,Figueroa, Ruth
supporting information; experimental part, p. 3477 - 3479 (2009/05/27)
(Chemical Equation Presented) A highly stereoselective synthesis of chiral α-amino-β-lactam through an ynamide-Kinugasa reaction is described. In addition, a mechanistic model is illustrated here to rationalize the observed diastereoselectivity, which depends on both the initial [3 + 2] cycloaddition step and the subsequent protonation for which both are highly selective.
