104040-76-8

Usage

Uses

Used in Pharmaceutical Development:
3-(Trifluoromethyl)-2-pyridinesulfonamide is utilized as a key building block in the synthesis of various pharmaceuticals. Its unique structure allows for the development of new drugs with potential therapeutic applications.
Used in Organic Synthesis:
In the field of organic synthesis, 3-(Trifluoromethyl)-2-pyridinesulfonamide serves as a valuable intermediate, enabling the creation of a wide range of chemical compounds with diverse properties and functions.
Used in Medicinal Chemistry:
3-(Trifluoromethyl)-2-pyridinesulfonamide is employed as a starting material in medicinal chemistry, facilitating the design and synthesis of novel therapeutic agents with improved efficacy and selectivity.
Used in Anti-inflammatory Applications:
3-(Trifluoromethyl)-2-pyridinesulfonamide has been investigated for its potential anti-inflammatory properties, making it a promising candidate for the development of new anti-inflammatory drugs.
Used in Anti-cancer Applications:
3-(Trifluoromethyl)-2-pyridinesulfonamide has also been studied for its potential anti-cancer properties, indicating its potential use in the development of novel cancer therapeutics.
Used in Biological Research:
3-(Trifluoromethyl)-2-pyridinesulfonamide can serve as a useful tool in the study of biological processes, providing insights into the mechanisms of various diseases and conditions.
Used in Metal Coordination Chemistry:
In the field of metal coordination chemistry, 3-(Trifluoromethyl)-2-pyridinesulfonamide acts as a ligand, contributing to the development of new metal complexes with potential applications in catalysis, sensing, and other areas.

Upstream product

• 65753-47-1 2-chloro-3-trifluoromethyl-pyridine 
• 104040-75-7 3-trifluoromethylpyridine-2-sulfonyl chloride 
• 104040-74-6 3-trifluoromethyl-2-mercaptopyridine 
• 104040-78-0 flazasulfuron 
• 181313-25-7 3-(trifluoromethyl)-2-pyridylsulfonylmethylcarbamate 

Downstream Products

• 104040-78-0 flazasulfuron 

Relevant academic research and scientific papers

Preparation method N -methoxycarbonyl -3 -trifluoromethylpyridine -2 - sulfanilamide

The invention relates to a preparation method of N - methoxycarbonyl -3 -trifluoromethylpyridine -2 - sulfanilamide, and belongs to the technical field of organic synthesis. The preparation method comprises the following steps: preparing 3 -trifluoromethylpyridine -2 - sulfonyl chloride containing urea and acid. Methyl carbamate is obtained as a raw material, and then 3 - trifluoromethylpyridine -2 - sulfonyl chloride and methyl carbamate are used as raw materials to obtain N - methoxycarbonyl -3 - trifluoromethylpyridine -2 - sulfanilamide. The preparation method disclosed by the invention has the advantages of few reaction steps, simple reaction conditions and cheap and accessible raw materials.

Flazasulfuron: Alcoholysis, Chemical Hydrolysis, and Degradation on Various Minerals

The herbicide flazasulfuron undergoes rapid alcoholysis. High yields of the corresponding carbamate and aminopyrimidine are obtained after the alcoholysis process (methanol or ethanol) at 30 °C in the course of which the concomitant rearrangement reaction remains minor. Hydrolysis (pH ranging from 5 to 11) of flazasulfuron at 30 °C principally involves the rearrangement into urea after elimination of S02 and can lead, in a small proportion, to both aminopyrimidine and pyridinesulfonamide. First-order kinetics correctly describes the rates of alcoholysis and hydrolysis. The sulfonylurea-bridge contraction and final transformation into the correspondent amine were evaluated with a first-order kinetics hypothesis. Transformations in amine and urea in aqueous medium are pH dependent. The chemical degradation of flazasulfuron on various dry minerals (calcium bentonite, kaolinite, silica, montmorillonite, and alumina) was investigated at 30 °C. The rearrangement reaction is the only one observed in the presence of kaolinite and alumina. However, hydrolysis and rearrangement have the same reaction rate in the presence of silica. The hydrolysis paths of flazasulfuron are comparable to the ones described for rimsulfuron.

N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-3-trifluoromethylpyridine-2-sulfonamide or salts thereof, herbicidal composition containing the same

N-[(4,6-Dimethoxypyrimidin-2-yl)aminocarbonyl]-3-trifluoromethylpyridine-2-sulfonamide or a salt thereof is disclosed. The compound of the invention is useful as a herbicide which has an extremely high herbicidal effect against a wide variety of weeds inc