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1040400-87-0

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1040400-87-0 Usage

Description

2-AMINO-5-FLUOROBENZENEBORONIC ACID is a boronic acid derivative characterized by the molecular formula C6H7BFNO2. It features a benzene ring with a fluorine atom and an amino group attached, which endows it with unique chemical properties and reactivity. 2-AMINO-5-FLUOROBENZENEBORONIC ACID is a versatile building block in the fields of organic synthesis and medicinal chemistry, utilized for the creation of pharmaceuticals and agrochemicals.

Uses

Used in Organic Synthesis:
2-AMINO-5-FLUOROBENZENEBORONIC ACID is used as a building block for the synthesis of various organic compounds due to its reactivity and the ability to form stable intermediates in chemical reactions.
Used in Medicinal Chemistry:
In the pharmaceutical industry, 2-AMINO-5-FLUOROBENZENEBORONIC ACID is used as a key intermediate in the development of new drugs, leveraging its structural features to enhance the pharmacological properties of medicinal agents.
Used in Suzuki-Miyaura Coupling Reactions:
2-AMINO-5-FLUOROBENZENEBORONIC ACID is employed as a reagent in Suzuki-Miyaura coupling reactions, a widely used method for forming carbon-carbon bonds in organic synthesis, facilitating the creation of complex molecular structures.
Used in Therapeutic Applications:
2-AMINO-5-FLUOROBENZENEBORONIC ACID has been studied for its potential as a therapeutic agent, particularly in the treatment of cancer and other diseases, due to its ability to interact with biological targets and modulate cellular processes.

Check Digit Verification of cas no

The CAS Registry Mumber 1040400-87-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,4,0,4,0 and 0 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1040400-87:
(9*1)+(8*0)+(7*4)+(6*0)+(5*4)+(4*0)+(3*0)+(2*8)+(1*7)=80
80 % 10 = 0
So 1040400-87-0 is a valid CAS Registry Number.

1040400-87-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-Amino-5-fluorophenylboronic acid

1.2 Other means of identification

Product number -
Other names (2-amino-5-fluorophenyl)boronic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1040400-87-0 SDS

1040400-87-0Relevant articles and documents

Synthesis and evaluation of the tetracyclic ring-system of isocryptolepine and regioiso-mers for antimalarial, antiproliferative and antimicrobial activities

Albrigtsen, Marte,Andersen, Jeanette H.,Avery, Vicky M.,H?heim, Katja S.,Helgeland, Ida T. Urdal,Kennedy, Emily K.,Lauga, Clémence,Lindb?ck, Emil,Matringe, Théodora,Sydnes, Magne O.,Tan, Kah Ni

, (2021/06/16)

A series of novel quinoline-based tetracyclic ring-systems were synthesized and evaluated in vitro for their antiplasmodial, antiproliferative and antimicrobial activities. The novel hydroiodide salts 10 and 21 showed the most promising antiplasmodial inhibition, with compound 10 displaying higher selectivity than the employed standards. The antiproliferative assay revealed novel pyridophenanthridine 4b to be significantly more active against human prostate cancer (IC50 = 24 nM) than Puromycin (IC50 = 270 nM) and Doxorubicin (IC50 = 830 nM), which are used for clinical treatment. Pyridocarbazoles 9 was also moderately effective against all the employed cancer cell lines and moreover showed excellent biofilm inhibition (9a: MBIC = 100 μM; 9b: MBIC = 100 μM).

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