1040401-18-0 Usage
Description
4-Mercaptomethyl Dipicolinic Acid is a pale yellow solid that serves as a versatile tag for various applications in the field of biochemistry and molecular biology. It is particularly known for its ability to bind lanthanide ions with high affinity, making it a valuable tool for protein tagging and paramagnetic NMR spectroscopy.
Uses
Used in Biochemistry and Molecular Biology:
4-Mercaptomethyl Dipicolinic Acid is used as a Dipicolinic acid tag for rigid lanthanide tagging of proteins and paramagnetic NMR Spectroscopy. The tag binds lanthanide ions with nanomolar affinity, allowing for the attachment to proteins via a disulfide bond. This unique property helps avoid the issues of diastereomer formation associated with most conventional lanthanide tags, making it a preferred choice for researchers in the field.
In addition to its primary use in protein tagging and NMR spectroscopy, 4-Mercaptomethyl Dipicolinic Acid may also find applications in other areas of research and development, such as drug delivery systems or as a component in the synthesis of novel compounds with specific properties.
Check Digit Verification of cas no
The CAS Registry Mumber 1040401-18-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,4,0,4,0 and 1 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1040401-18:
(9*1)+(8*0)+(7*4)+(6*0)+(5*4)+(4*0)+(3*1)+(2*1)+(1*8)=70
70 % 10 = 0
So 1040401-18-0 is a valid CAS Registry Number.
1040401-18-0Relevant articles and documents
Lanthanide-based hydrogels with adjustable luminescent properties synthesized by thiol-Michael addition
Li, Qing-Feng,Chu, Shaowen,Li, Erqing,Li, Meng,Wang, Jin-Tao,Wang, Zhenling
, (2020)
Luminescent hydrogels have been widely used in many fields because of their excellent optical properties. Although there are many mature preparation methodologies, the development of new luminescent hydrogels with adjustable fluorescence properties and good mechanical properties is still an urgent need to explore. In this paper, we describe a simple and effective way to synthesize highly luminescent PVA/AM-Ln(DPA)3 double network hydrogels by thiol-Michael addition reaction and in situ polymerization. We firstly synthesized a bifunctional chelating ligand named as 4-(mercaptomethyl)pyridine-2,6-dicarboxylic acid, which can react with electron-deficient carbon-carbon double bonds and effectively sensitize the luminescence of Tb3+ and Eu3+ ions. And then, the luminescent lanthanide complexes were grafted onto the methacrylated polyvinyl alcohol via thiol-Michael addition reaction. Finally, the modified polymers were polymerized with acrylamide monomer to form the luminescent double network hydrogels. The obtained hydrogels possess bright luminescence, long luminescence lifetimes and good mechanical properties. Moreover, the emission colors of the hydrogels are adjustable by varying the molar ratio of Eu3+and Tb3+.
