1040428-08-7Relevant academic research and scientific papers
Highly enantioselective synthesis of 2-furanyl-hydroxyacetates from furans via the Friedel-Crafts reaction
Majer, Jakub,Kwiatkowski, Piotr,Jurczak, Janusz
, p. 2955 - 2958 (2008)
(Chemical Equation Presented) The Friedel-Crafts reaction of alkyl glyoxylates with variously substituted furans was found to be efficiently catalyzed under simple, undemanding conditions by a 6,6′-dibromo-BINOL/ Ti(IV) complex with high enantioselectivity. The reaction afforded chiral substituted 2-furanyl-hydroxyacetic acid esters, compounds of high synthetic interest, in good yield and enantiomeric excess, in most examples in the range of 90-97%.
