1040455-23-9

Upstream product

• 1517-69-7 (R)-1-phenylethanol 
• 390357-37-6 (rac)-2,8-diiodo-4,10-dimethyl-5,11-methano-6H,12H-dibenzo[b,f][1,5]diazocine 
• 1040455-25-1 2,8-bis[(R)-1-phenylethoxy]-4,10-dimethyl-6H,12H-5,11-methanodibenzodiazocine 

Relevant academic research and scientific papers

Synthesis, resolution, and absolute configuration of difunctionalized Troeger's base derivatives

Two racemic derivatives of Troeger's base, the 2,8-diboronic acid ester 6 and the 3,9-dibromo-substituted derivative 5, were synthesized and successfully resolved by HPLC on a chiral stationary Whelk-01 phase on a semipreparative scale, thereby giving rise to both enantiomers in a pure form. These functionalized C2symmetric building blocks are valuable precursors for a variety of further applications. Their absolute configurations were determined by comparison of their quantum chemically calculated CD and UV/Vis spectra with the experimental ones and were independently confirmed by X-ray diffraction analysis.