1040502-51-9

Basic information

• Product Name: 3-(methylthio)-1H-indazole
• Synonyms: 3-(methylthio)-1H-indazole;3-Methylsulfanyl-1H-indazole;1H-Indazole,3-(methylthio)-
• CAS NO: 1040502-51-9
• Molecular Formula: C₈H₈N₂S
• Molecular Weight: 164.22752
• Mol File: 1040502-51-9.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Density: 1.29±0.1 g/cm3 (20 ºC 760 Torr)
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-(methylthio)-1H-indazole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(methylthio)-1H-indazole(1040502-51-9)
• EPA Substance Registry System: 3-(methylthio)-1H-indazole(1040502-51-9)

Safety Data

• Hazardous Substances Data: 1040502-51-9(Hazardous Substances Data)

Usage

General Description

3-(methylthio)-1H-indazole is a chemical compound with the molecular formula C8H8N2S. It is an indazole derivative that contains a methylthio group attached to the third carbon atom of the indazole ring. 3-(methylthio)-1H-indazole is known for its potential pharmacological and biological activities, and it has been studied for its potential use in the development of new drugs. It may also have applications in organic synthesis and medicinal chemistry. 3-(methylthio)-1H-indazole is a promising compound for further research and exploration in various scientific fields.

Upstream product

• 5188-07-8 sodium thiomethoxide 
• 29110-74-5 3-chloroindazole 

Downstream Products

• 1040502-47-3 1-(2,6-dichloro-4-trifluoromethyl-phenyl)-3-methylsulfanyl-1H-indazole 

Relevant articles and documents

Discovery of methylsulfonyl indazoles as potent and orally active respiratory syncytial Virus(RSV) fusion inhibitors

Recently we described a novel class of imidazopyridine compounds that showed exceptional anti-RSV potency in cell culture. However, unfavorable pharmacokinetic (PK) properties and glutathione (GSH) adduct liabilities impeded their further development. In a bid to address the PK and early safety concerns, a small compound library consisting of dozens of scaffold-hopping analogues was designed and synthesized for RSV CPE assay screening, which led to the identification of a new chemical starting point: methylsulfonyl indole compound 8. In this paper, we report the discovery and optimization of a series of methylsulfonyl indazoles as potent RSV fusion inhibitors. In particular, compound 47 was orally efficacious in a RSV mouse model, with 1.6 log unit viral load reduction at 25 mg/kg BID upon oral dosing. The results may have broad implications for the design of new RSV fusion inhibitors, and demonstrate the potential for developing novel therapies for RSV infection.

ORGANIC COMPOUNDS

The invention relates to compounds of the general formula (I), wherein R1, R2, Q, X, m and n have the meanings given in the claims, and optionally the enantiomers thereof. The active ingredients have advantageous pesticidal properties. They are especially suitable for controlling parasites on warm-blooded animals and plants.