104057-07-0Relevant academic research and scientific papers
Uncatalyzed and solvent-free multicomponent process for the synthesis of biphenyl-2-carbonitrile derivatives
Fringuelli, Francesco,Girotti, Rugiada,Piermatti, Oriana,Pizzo, Ferdinando,Vaccaro, Luigi
, p. 5741 - 5744 (2007/10/03)
(Diagram presented) An innovative route to prepare a number of variously substituted new biphenyl derivatives is presented here. The protocol avoids the use of a catalyst, an organic solvent, and dry conditions.
Effect of microwave irradiation on reaction of arylaldehyde derivatives with some active methylene compounds in aqueous media
Valizadeh, Hassan,Mamaghani, Manouchehr,Badrian, Abed
, p. 785 - 790 (2007/10/03)
The effect of microwave irradiation on the condensation reactions of arylaldehydes 1 and active methylene compounds 2 in aqueous media was studied and compared with "classical" conditions. The results show that the condensation was carried out only under microwave irradiation in the presence of ammonium chloride as a catalyst, followed by dehydration, to afford (E)-olefins 3. The protocol was used to synthesize coumarins by a condensation reaction of salicylaldehyde or its derivatives with various derivatives of ethylacetate 5 (e.g., R3CH2CO2Et; R3: CO 2Et, CO2Me, COMe, CN) in high yields. These investigations will contribute to the development of environmentally friendly and inexpensive processes in organic synthesis.
