104060-49-3

Basic information

• Product Name: C₁₆H₁₆N₂O₃
• CAS NO: 104060-49-3
• Molecular Weight: 284.315
• Mol File: 104060-49-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₁₆H₁₆N₂O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₆H₁₆N₂O₃(104060-49-3)
• EPA Substance Registry System: C₁₆H₁₆N₂O₃(104060-49-3)

Safety Data

• Hazardous Substances Data: 104060-49-3(Hazardous Substances Data)

Upstream product

• 15028-39-4 L-2-phenylglycine methyl ester hydrochloride 
• 103-71-9 phenyl isocyanate 
• 62-53-3 aniline 
• 2935-35-5 (S)-2-phenylglycine 
• 32315-10-9 bis(trichloromethyl) carbonate 

Downstream Products

• 116346-35-1 C₁₅H₁₆N₂O₂ 
• 1294004-73-1 C₄₀H₃₈N₄O₈ 
• 1401335-08-7 (S)-N-hydroxy-2-phenyl-2-(3-phenylureido)acetamide 

Relevant articles and documents

Development of synthetic aminopeptidase N/CD13 inhibitors to overcome cancer metastasis and angiogenesis

Cancer metastasis is a major barrier to its treatment and an important cause of patient death. Antimetastatic agents hold promise for patients with advanced metastatic tumors. Aminopeptidase N/CD13 (APN) is being pursued by many as an important target against cancer metastasis and angiogenesis, but there are few reports on the in vivo evaluation of synthetic APN inhibitors. Herein, a series of compounds targeting APN were synthesized and evaluated for their antimetastasis and antiangiogenesis potency both in vitro and in vivo. Excitingly, compounds 4m, 4t, and 4cc, with the most potent APN inhibitory activities, displayed significant antimetastasis and antiangiogenesis effects in vitro and in vivo, suggesting that those synthetic APN inhibitors have the potential to overcome cancer metastasis and angiogenesis.