104070-97-5Relevant articles and documents
Substituted 1,3,4-Thiadiazoles with Anticonvulsant Activity. 1. Hydrazines
Chapleo, Christopher B.,Myers, Malcolm,Myers, Peter L.,Saville, John F.,Smith, Alan C. B.,et al.
, p. 2273 - 2280 (2007/10/02)
The synthesis and anticonvulsant activity of a series of 2-aryl-5-hydrazino-1,3,4-thiadiazoles are described.The combination of preferred aromatic substituents in the 2-position coupled with alkyl substitution on the hydrazine moiety led to a number of potent compounds lacking sedation, ataxia, or lethality. 5-(2-Biphenylyl)-2-(1-methylhydrazino)-1,3,4-thiadiazole (4m) represents a new class of anticonvulsant agent and compares favorably with the standard drugs phenytoin, phenobarbital, and carbamazepine.