104075-48-1 Usage
Uses
Atipamezole Hydrochloride, is the a synthetic α2-adrenergic antagonist, usually used to reverse the sedative and analgesic effects of dexmedetomidine and medetomidine in dogs. It has also been shown to be used as possible anti-Parkinsonian drug in humans.
Biological Activity
Selective α 2 -adrenergic receptor antagonist (K i values are 1.1, 1.0, 0.89, 1300 and 6500 nM for α 2A , α 2B , α 2C , α 1A and α 1B receptors respectively). Brain penetrant.
Veterinary Drugs and Treatments
Atipamezole is labeled for use as a reversal agent for medetomidine
and dexmedetomidine. It potentially
could be useful for reversal
of other alpha2-adrenergic agonists as well (e.g., amitraz, xylazine,
clonidine, tizanidine, brimonidine).
Check Digit Verification of cas no
The CAS Registry Mumber 104075-48-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,4,0,7 and 5 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 104075-48:
(8*1)+(7*0)+(6*4)+(5*0)+(4*7)+(3*5)+(2*4)+(1*8)=91
91 % 10 = 1
So 104075-48-1 is a valid CAS Registry Number.
InChI:InChI=1/C14H16N2.ClH/c1-2-14(13-9-15-10-16-13)7-11-5-3-4-6-12(11)8-14;/h3-6,9-10H,2,7-8H2,1H3,(H,15,16);1H
104075-48-1Relevant articles and documents
Preparation process of atipamezole hydrochloride
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Paragraph 0029; 0031; 0033; 0035; 0037, (2020/12/08)
The invention relates to the technical field of preparation of compounds, in particular to a preparation process of atipamezole hydrochloride. The preparation process comprises the following operationsteps: 1) reacting 4-(2-ethyl-2-indanone) imidazole and alkali in an organic solvent; 2) adding hydrazine hydrate into the reaction solution obtained in the step 1) to obtain atemeconazole; and 3) adding the atemeconazole obtained in the reaction 2) into concentrated hydrochloric acid for salifying to obtain atemeconazole hydrochloride. At present, the industrial synthesis of the atemeconazole hydrochloride in the prior art is low in yield and high in cost; the invention provides a brand-new preparation process of the atenomezole, which effectively improves the reaction efficiency, synthesizes the atenomezole with high selectivity, reduces byproducts, effectively reduces the discharge of waste water and waste gas and is beneficial to industrial production.
