1040753-95-4Relevant academic research and scientific papers
Electrophile-induced ether transfer: Stereoselective synthesis of 2,6-disubstituted-3,4-dihydropyrans
Kartika, Rendy,Frein, Jeffrey D.,Taylor, Richard E.
, p. 5592 - 5594 (2008/12/20)
(Chemical Equation Presented) Stereoselective synthesis of trans-2,6-disubstituted-3,4-dihydropyrans has been achieved from a simple homoallylic alkoxyether via a three-step sequence: electrophile-induced ether transfer, cyclization, and functionalization, which is highlighted by a rare example of Ferrier rearrangement of allylic ether. This methodology was successfully implemented for the asymmetric synthesis of a C7-C17 fragment of swinholide A.
