1040769-68-3Relevant academic research and scientific papers
Soft metal-mediated base pairing with novel synthetic nucleosides possessing an O,S-donor ligand
Takezawa, Yusuke,Tanaka, Kentaro,Yori, Maiko,Tashiro, Shohei,Shiro, Motoo,Shionoya, Mitsuhiko
, p. 6092 - 6098 (2008)
(Chemical Equation Presented) Metal-mediated base pairing with artificial ligand-bearing nucleosides allows site-selective metal incorporation inside DNA duplexes. In particular, this strategy has provided a general way of discrete, heterogeneous metal arrays in a programmable manner. To increase the kind of metallo-building blocks, we have newly synthesized two artificial nucleosides which have an O,S-donor ligand as the nucleobase moiety, mercaptopyridone (M) and hydroxypyridinethione (S). These nucleosides were found to efficiently form metal-mediated base pairs with soft transition metal ions such as Pd 2+ and Pt2+.
