10408-65-8

Basic information

• Product Name: 1H-Benz[e]inden-1-one, 2,3-diphenyl-
• CAS NO: 10408-65-8
• Molecular Formula: C25H16O
• Molecular Weight: 332.401
• Mol File: 10408-65-8.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 1H-Benz[e]inden-1-one, 2,3-diphenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Benz[e]inden-1-one, 2,3-diphenyl-(10408-65-8)
• EPA Substance Registry System: 1H-Benz[e]inden-1-one, 2,3-diphenyl-(10408-65-8)

Safety Data

• Hazardous Substances Data: 10408-65-8(Hazardous Substances Data)

Upstream product

• 501-65-5 diphenyl acetylene 
• 2243-83-6 2-naphthaloyl chloride 
• 66-77-3 1-naphthaldehyde 
• 86-55-5 1-naphthalenecarboxylic acid 
• 2459-24-7 methyl 1-naphthoate 
• 86-53-3 1-Cyanonaphthalene 
• 103408-15-7 iodo-2 naphthalene carbonitrile-1 
• 10408-69-2 2,3-Diphenyl-3-(2'-naphthyl)-3-hydropropionsaeure 
• 879-18-5 naphthalene-1-carbonic acid chloride 
• 38060-48-9 2-phenyl-cyclopenta[a]naphthalene-1,3-dione 

Relevant articles and documents

Mechanochemical Solvent-Free Synthesis of Indenones from Aromatic Carboxylic Acids and Alkynes

The mechanochemical solvent-free synthesis of indenones from aromatic carboxylic acids and alkynes was achieved through triflic anhydride (Tf2O)-induced cyclization reaction. A variety of indenones including a bioactive PPARγagonist were obtained in up to 90% yield at room temperature. The present protocol has the advantages of mild reaction conditions, high reaction efficiency, and feasibility of scalable synthesis, providing a facile and sustainable route to diverse indenones.

Cobalt(III)-catalyzed annulation of esters and alkynes: A facile route to indenones

An efficient protocol for the synthesis of indenones has been developed via the annulation of benzoic esters and internal alkynes by exploiting the cobalt catalyst.

Carbopalladation of nitriles: Synthesis of 2,3-diarylindenones and polycyclic aromatic ketones by the Pd-catalyzed annulation of alkynes and bicyclic alkenes by 2-iodoarenenitriles

2-Iodobenzonitrile, its derivatives, and various heterocyclic analogues undergo palladium(O)-catalyzed annulation onto diarylacetylenes or bicyclic alkenes to afford 2,3-diarylindenones and polycyclic aromatic ketones in very good to excellent yields. This reaction represents one of the first examples of the addition of an organopalladium moiety to the carbon-nitrogen triple bond of a nitrile. The reaction is compatible with a number of functional groups. A reaction mechanism, as well as a model accounting for the electronic effects of substituents on the aromatic ring of the nitrile, is proposed.