1040861-09-3

Basic information

• Product Name: C₈H₅Cl₂FO
• Synonyms: C₈H₅Cl₂FO
• CAS NO: 1040861-09-3
• Molecular Weight: 207.032
• Mol File: 1040861-09-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: C₈H₅Cl₂FO(CAS DataBase Reference)
• NIST Chemistry Reference: C₈H₅Cl₂FO(1040861-09-3)
• EPA Substance Registry System: C₈H₅Cl₂FO(1040861-09-3)

Safety Data

• Hazardous Substances Data: 1040861-09-3(Hazardous Substances Data)

Upstream product

• 261762-96-3 2-(3-chloro-2-fluorophenyl)acetic acid 
• 261762-98-5 2-(3-chloro-2-fluorophenyl)acetonitrile 
• 85070-47-9 1-(bromomethyl)-3-chloro-2-fluorobenzene 

Downstream Products

• 956026-08-7 C₁₆H₁₇ClFN₅ 
• 1428640-33-8 C₁₅H₁₅ClFN₅ 
• 1428640-57-6 C₁₂H₉ClFN₅ 
• 1428640-50-9 C₁₅H₁₆ClFN₄ 

Relevant articles and documents

Phosphonic acid analogs of fluorophenylalanines as inhibitors of human and porcine aminopeptidases N: Validation of the importance of the substitution of the aromatic ring

A library of phosphonic acid analogs of phenylalanine substituted with fluorine, chlorine and trifluoromethyl moieties on the aromatic ring was synthesized and evaluated for inhibitory activity against human (hAPN) and porcine (pAPN) aminopeptidases. Fluorogenic screening indicated that these analogs are micromolar or submicromolar inhibitors, both enzymes being more active against hAPN. In order to better understand the mode of the action of the most active compounds, molecular modeling was used. It confirmed that aminophosphonic portion of the enzyme is bound nearly identically in the case of all the studied compounds, whereas the difference in activity results from the placement of aromatic side chain of an inhibitor. Interestingly, both enantiomers of the individual compounds are usually bound quite similarly.

ARYL FLUOROETHYL UREAS ACTING AS ALPHA 2 ADRENERGIC AGENTS

The invention provides well-defined aryl fluoroethyl ureas that are useful as selective alpha2 adrenergic agonists. As such, the compounds described herein are useful in treating a wide variety of disorders associated with modulation of alpha2 adrenergic receptors.