1040876-91-2

Basic information

• Product Name: C₃₈H₄₀N₂O₁₁
• Synonyms: C₃₈H₄₀N₂O₁₁
• CAS NO: 1040876-91-2
• Molecular Weight: 700.742
• Mol File: 1040876-91-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₃₈H₄₀N₂O₁₁(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₈H₄₀N₂O₁₁(1040876-91-2)
• EPA Substance Registry System: C₃₈H₄₀N₂O₁₁(1040876-91-2)

Safety Data

• Hazardous Substances Data: 1040876-91-2(Hazardous Substances Data)

Upstream product

• 3505-67-7 1,6-dioxaspiro[4.4]nonane-2,7-dione 
• 40615-39-2 5'-O-(4-4'-dimethoxytrityl)thymidine 

Relevant articles and documents

4-Oxoheptanedioic acid: an orthogonal linker for solid-phase synthesis of base-sensitive oligonucleotides

l,6-Dioxaspiro[4,4]nonane-2,7-dione has been found to react readily with alcohols in the presence of 1,8-diazabicyclo[5,4,0]undec-7-ene (DBU). The 4-oxoheptanedioic acid tether obtained bears (l) a free carboxy group, which enables anchoring to aminoalkylated resins, and (2) a 4-oxobutanoate structural motif, which allows release of the target alcohol by a mild hydrazinium acetate treatment. To demonstrate the applicability of the procedure, nucleosides have been derivatized with this simple difunctional linker arm, anchored to a solid phase and subjected to synthesis and subsequent release of oligonucleotides bearing a base-sensitive biodegradable phosphate protection.