1040882-94-7Relevant articles and documents
Synthesis of fluorogenic polymers for visualizing cellular internalization
Mangold, Shane L.,Carpenter, Rachael T.,Kiessling, Laura L.
, p. 2997 - 3000 (2008)
(Chemical Equation Presented) The binding of a polymeric ligand to a cell surface receptor can promote its internalization. Methods to track and visualize multivalent ligands within a cell can give rise to new therapeutic strategies and illuminate signaling processes. We have used the features of the ring-opening metathesis polymerization (ROMP) to develop a general strategy for synthesizing multivalent ligands equipped with a latent fluorophore. The utility of ligands of this type is highlighted by visualizing multivalent antigen internalization in live B cells.