1040908-34-6

Basic information

• Product Name: (S)-3-(2-nitro-1-(4-(trifluoromethyl)phenyl)ethyl)-1H-indole
• Synonyms: (S)-3-(2-nitro-1-(4-(trifluoromethyl)phenyl)ethyl)-1H-indole
• CAS NO: 1040908-34-6
• Molecular Weight: 334.298
• Mol File: 1040908-34-6.mol

Chemical Properties

• CAS DataBase Reference: (S)-3-(2-nitro-1-(4-(trifluoromethyl)phenyl)ethyl)-1H-indole(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-3-(2-nitro-1-(4-(trifluoromethyl)phenyl)ethyl)-1H-indole(1040908-34-6)
• EPA Substance Registry System: (S)-3-(2-nitro-1-(4-(trifluoromethyl)phenyl)ethyl)-1H-indole(1040908-34-6)

Safety Data

• Hazardous Substances Data: 1040908-34-6(Hazardous Substances Data)

Upstream product

• 120-72-9 indole 
• 93628-97-8 1-(2-nitrovinyl)-4-trifluoromethylbenzene 
• 3156-51-2 3-[(E)-2-nitroeth-1-enyl]-1H-indole 
• 128796-39-4 4-trifluoromethylphenylboronic acid 
• 487-89-8 Indole-3-carboxaldehyde 

Relevant articles and documents

Reversible modulation of the activity of thiourea catalysts with anions: A simple approach to switchable asymmetric catalysis

Leveraging the anion binding properties of thioureas, we show that the activity of known well-performing chiral catalysts can be reduced by coordinating anions (e.g. chloride) and restored by anion metatheses. Three benchmark enantioselective transformati

Exploiting the chiral ligands of bis(Imidazolinyl)-and bis(oxazolinyl)thiophenes—Synthesis and application in Cu-catalyzed friedel–crafts asymmetric alkylation

Five new C2-symmetric chiral ligands of 2,5-bis(imidazolinyl)thiophene (L1–L3) and 2,5-bis(oxazolinyl)thiophene (L4 and L5) were synthesized from thiophene-2,5-dicarboxylic acid (1) with enantiopure amino alcohols (4a–c) in excellent optical purity and chemical yield. The util-ity of these new chiral ligands for Friedel–Crafts asymmetric alkylation was explored. Subse-quently, the optimized tridentate ligand L5 and Cu(OTf)2 catalyst (15 mol%) in toluene for 48 h promoted Friedel–Crafts asymmetric alkylation in moderate to good yields (up to 76%) and with good enantioselectivity (up to 81% ee). The bis(oxazolinyl)thiophene ligands were more potent than bis(imidazolinyl)thiophene analogues for the asymmetric induction of the Friedel–Crafts asymmetric alkylation.

Rhodium-catalyzed asymmetric addition of arylboronic acids to indolylnitroalkenes

Indolylnitroethanes and their derivatives are key intermediates to many bioactive structures. Most approaches to access chiral indolylnitroethanes involve organocatalyzed or metal-catalyzed asymmetric Friedel-Crafts reaction of indoles with nitroalkenes.

Chiral phosphoric acid catalyzed enantioselective Friedel-Crafts alkylation of indoles with nitroalkenes: Cooperative effect of 3 A molecular sieves

(Chemical Equation Presented) Crafty catalysts: Friedel-Crafts alkylation of indoles with nitroalkenes proceeded in the presence of phosphoric acid 1 and 3 A molecular sieves to give Friedel-Crafts adducts with excellent enantioselectivities (see scheme).