1040915-46-5Relevant academic research and scientific papers
Isocyanide addition to acylphosphonates: A formal Passerini reaction of acyl chlorides
Coffinier, Didier,El Kaim, Laurent,Grimaud, Laurence
body text, p. 1133 - 1136 (2009/04/07)
Acylphosphonates behave as carbonyl components in Passerini reactions with isocyanides and carboxylic acids. Under saponification, the adducts undergo a phospha-Brook rearrangement to form α-amidophosphates. As acylphosphonates are quantitatively formed from carboxylic derivatives, this new reductive procedure allows acyl chlorides to react as aldehydes in a Passerini-type reaction. Georg Thieme Verlag Stuttgart.
