1041006-69-2Relevant academic research and scientific papers
Chemoenzymatic synthesis of (+)-α-polypodatetraene and methyl (5R,10R,13R)-labda-8-en-15-oate
Kinoshita, Masako,Miyake, Takahiro,Arima, Yuusuke,Oguma, Minako,Akita, Hiroyuki
, p. 118 - 123 (2008/09/17)
The reported enzymatic resolution products {acetate of (1S,4aS,8aS)-1,2,3, 4,4a,5,6,7,8,8a-decahydro-5,5,8a-trimethyl-2-oxo-trans-naphthalene-1-methanol-2- ethylene acetal} (8aS)-5 (>99% ee)] and [(1R,4aR,8aR)-1,2,3,4,4a,5,6,7,8,8a- decahydro-5,5,8a-trimethyl-2-oxo-trans-naphthalene-1-methanol-2-ethylene acetal (8aR)-4 (98% ee) were converted to (+)-α-polypodatetraene (1) and methyl (5R,10R,13R)-labda-8-en-15-oate (2), respectively. For the synthesis of (5R,10R,13R)-2, chiral isoprene congener (3S)-26 corresponding to the right part of 2 was synthesized based on the lipase-assisted resolution of (±)-2-methyl-3- (p-methoxyphenyl)propanol (17).
