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1041016-36-7

ethyl 5-(chlorocarbonyl)-3-(2,4-difluorobenzamido)-6,6-dimethyl-5,6-dihydropyrrolo[3,4-c]pyrazole-2(4H)-carboxylate is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • ethyl 5-(chlorocarbonyl)-3-(2,4-difluorobenzamido)-6,6-dimethyl-5,6-dihydropyrrolo[3,4-c]pyrazole-2(4H)-carboxylate

    Cas No: 1041016-36-7

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  • 1041016-36-7 Structure

  • Basic information

    1. Product Name: ethyl 5-(chlorocarbonyl)-3-(2,4-difluorobenzamido)-6,6-dimethyl-5,6-dihydropyrrolo[3,4-c]pyrazole-2(4H)-carboxylate
    2. Synonyms:
    3. CAS NO:1041016-36-7
    4. Molecular Formula:
    5. Molecular Weight: 426.807
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1041016-36-7.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: ethyl 5-(chlorocarbonyl)-3-(2,4-difluorobenzamido)-6,6-dimethyl-5,6-dihydropyrrolo[3,4-c]pyrazole-2(4H)-carboxylate(CAS DataBase Reference)
    10. NIST Chemistry Reference: ethyl 5-(chlorocarbonyl)-3-(2,4-difluorobenzamido)-6,6-dimethyl-5,6-dihydropyrrolo[3,4-c]pyrazole-2(4H)-carboxylate(1041016-36-7)
    11. EPA Substance Registry System: ethyl 5-(chlorocarbonyl)-3-(2,4-difluorobenzamido)-6,6-dimethyl-5,6-dihydropyrrolo[3,4-c]pyrazole-2(4H)-carboxylate(1041016-36-7)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1041016-36-7(Hazardous Substances Data)

1041016-36-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1041016-36-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,4,1,0,1 and 6 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1041016-36:
(9*1)+(8*0)+(7*4)+(6*1)+(5*0)+(4*1)+(3*6)+(2*3)+(1*6)=77
77 % 10 = 7
So 1041016-36-7 is a valid CAS Registry Number.

1041016-36-7Relevant articles and documents

Discovery of pyrroloaminopyrazoles as novel PAK inhibitors

Guo, Chuangxing,McAlpine, Indrawan,Zhang, Junhu,Knighton, Daniel D.,Kephart, Susan,Johnson, M. Catherine,Li, Haitao,Bouzida, Djamal,Yang, Anle,Dong, Liming,Marakovits, Joseph,Tikhe, Jayashree,Richardson, Paul,Guo, Lisa C.,Kania, Robert,Edwards, Martin P.,Kraynov, Eugenia,Christensen, James,Piraino, Joseph,Lee, Joseph,Dagostino, Eleanor,Del-Carmen, Christine,Deng, Ya-Li,Smeal, Tod,Murray, Brion W.

, p. 4728 - 4739 (2012)

The P21-activated kinases (PAK) are emerging antitumor therapeutic targets. In this paper, we describe the discovery of potent PAK inhibitors guided by structure-based drug design. In addition, the efflux of the pyrrolopyrazole series was effectively reduced by applying multiple medicinal chemistry strategies, leading to a series of PAK inhibitors that are orally active in inhibiting tumor growth in vivo.

CARBONYLAMINO PYRROLOPYRAZOLES, POTENT KINASE INHIBITORS

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Page/Page column 40, (2009/12/28)

Carbonylamino Pyrrolopyrazole compounds of formula I, compositions including these compounds and methods of their use are provided. Preferred compounds of formula I have activity as protein kinase inhibitors, including as inhibitors of PAK4.

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