1041050-76-3Relevant academic research and scientific papers
Optimization of α-ketoamide based p38 inhibitors through modifications to the region that binds to the allosteric site
Montalban, Antonio Garrido,Boman, Erik,Chang, Chau-Dung,Ceide, Susana Conde,Dahl, Russell,Dalesandro, David,Delaet, Nancy G.J.,Erb, Eric,Ernst, Justin T.,Gibbs, Andrew,Kahl, Jeffrey,Kessler, Linda,Kucharski, Jeff,Lum, Christopher,Lundstr?m, Jan,Miller, Stephen,Nakanishi, Hiroshi,Roberts, Edward,Saiah, Eddine,Sullivan, Robert,Urban, Jan,Wang, Zhijun,Larson, Christopher J.
scheme or table, p. 4819 - 4824 (2010/10/02)
We have optimized a novel series of potent p38 MAP kinase inhibitors based on an α-ketoamide scaffold through structure based design that due to their extended molecular architecture bind, in addition to the ATP site, to an allosteric pocket. In vitro ADM
CYTOKINE INHIBITORS
-
Page/Page column 162-163, (2008/12/07)
The present invention provides low molecular weight compounds useful as cytokine inhibitors, and compositions thereof. In particular, compounds of the invention are useful as anti-inflammatory agents. There are further provided methods for the preparation of such agents and their use in preventing or treating conditions mediated by cytokines, such as for example arthritis, pain, cardiovascular disease and cancer.
