1041190-95-7

Basic information

• Product Name: 1-(4-(hydroxymethyl)phenoxy)-3-(1-(5-phenylthieno[2,3-d]pyrimidin-4-yl)piperidin-4-ylamino)propan-2-ol
• CAS NO: 1041190-95-7
• Molecular Weight: 490.626
• Mol File: 1041190-95-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-(4-(hydroxymethyl)phenoxy)-3-(1-(5-phenylthieno[2,3-d]pyrimidin-4-yl)piperidin-4-ylamino)propan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-(hydroxymethyl)phenoxy)-3-(1-(5-phenylthieno[2,3-d]pyrimidin-4-yl)piperidin-4-ylamino)propan-2-ol(1041190-95-7)
• EPA Substance Registry System: 1-(4-(hydroxymethyl)phenoxy)-3-(1-(5-phenylthieno[2,3-d]pyrimidin-4-yl)piperidin-4-ylamino)propan-2-ol(1041190-95-7)

Safety Data

• Hazardous Substances Data: 1041190-95-7(Hazardous Substances Data)

Upstream product

• 660836-08-8 1-(5-phenyl-thieno[2,3-d]pyrimidine-4-yl)-piperidin-4-ylamine 
• 4204-78-8 2-{[4-(hydroxymethyl)phenoxy]methyl}oxirane 

Relevant articles and documents

Thienopyrimidines as β3-adrenoceptor agonists: Hit-to-lead optimization

Resulting from a vHTS based on a pharmacophore alignment on known β3-adrenoceptor ligands, an aryloxypropanolamine scaffold comprising a thienopyrimidine moiety was further optimized as a human β3-AR agonist, yielding a lead compound with an excellent cellular activity of EC50 = 20 pM, selectivity over hβ1- and hβ2-adrenoceptors and a promising safety profile.