1041201-64-2Relevant academic research and scientific papers
Synthesis of 2-[3-(7-Chloro-quinolin-4-ylamino)-alkyl]-1-(substituted phenyl)-2,3,4,9-tetrahydro-1H-β-carbolines as a new class of antimalarial agents
Gupta, Leena,Srivastava, Kumkum,Singh, Shubhra,Puri,Chauhan, Prem M.S.
scheme or table, p. 3306 - 3309 (2009/04/11)
A series of hybrid molecules 2-[3-(7-Chloro-quinolin-4-ylamino)-alkyl]-1-(substituted phenyl)-2,3,4,9-tetrahydro-1H-β-carbolines have been synthesized and screened for their in vitro antimalarial activity against chloroquine-sensitive strains of Plasmodium falciparum. Compounds 26, 32, and 34 have shown MIC in the range of 0.05-0.11 μM and are in vitro several folds more active than chloroquine.
