1041262-70-7Relevant articles and documents
Development of a concise synthesis of (-)-oseltamivir (Tamiflu)
Trost, Barry M.,Zhang, Ting
, p. 3630 - 3643 (2011/05/12)
We report a full account of our work towards the development of an eight-step synthesis of anti-influenza drug (-)-oseltamivir (Tamiflu) from commercially available starting materials. The final synthetic route proceeds with an overall yield of 30 %. Key transformations include a novel palladium-catalyzed asymmetric allylic alkylation reaction (Pd-AAA) as well as a rhodium-catalyzed chemo-, regio-, and stereoselective aziridination reaction.