1041403-35-3Relevant academic research and scientific papers
A hand natural alkyne propyl amine compound catalytic asymmetric synthesis method
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Paragraph 0084; 0085; 0086; 0087, (2018/02/04)
The invention provides a catalytic asymmetric synthesis method of chiral propargyl amine compounds. The catalytic asymmetric synthesis method is characterized by catalyzing asymmetric decarboxylation reactions in molecules of amide propargyl carbonate com
Enantioselective copper-catalyzed propargylic amination
Detz, Remko J.,Delville, Marielle M. E.,Hiemstra, Henk,Van Maarseveen, Jan H.
, p. 3777 - 3780 (2008/12/23)
(Chemical Equation Presented) A proper copper catalyst with a chiral pyridine-2,6-bisoxazoline (pybox) ligand was used to convert a variety of propargylic acetates with aromatic side chains (R = Ar) into their amine counterparts in high yield and with good selectivity (up to 88% ee). The resulting chiral propargylic amines can be elaborated further into P,N ligands (see scheme; DIPEA = diisopropylethylamine).
