1041424-91-2Relevant academic research and scientific papers
Investigations concerning the correlation of COX-1 inhibitory and hydroxyl radical scavenging activity
Scholz, Michael,Ulbrich, Holger,Mattern, Andreas,Kramb, Jan-Peter,Kiefer, Werner,Dannhardt, Gerd
experimental part, p. 281 - 287 (2009/04/04)
The aim was to study the COX-1 inhibiting efficacy in context with hydroxyl radical scavenging properties of compounds bearing a carboxylic acid and ester function, respectively. In general, the acids are more potent radical scavengers than the corresponding esters but there is no clear correlation with their COX-1 inhibiting potencies. A feasible scavenging mechanism of carboxylic acids is discussed.
