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10416-59-8

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Product FOB Price Min.Order Supply Ability Supplier
N,O-Bis(trimethylsilyl)acetamide
Cas No: 10416-59-8
USD $ 5.0-5.0 / Kilogram 1 Kilogram 1-1000 Metric Ton/Month Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
N,O-Bis(trimethylsilyl)acetamide 10416-59-8
Cas No: 10416-59-8
No Data 1 Kilogram 5 Metric Ton/Day Hangzhou J&H Chemical Co., Ltd. Contact Supplier
N,O-Bis(trimethylsilyl)acetamide
Cas No: 10416-59-8
USD $ 777.0-888.0 / Kilogram 1 Kilogram 1000 Kilogram/Month Enke Pharma-tech Co.,Ltd. (Cangzhou, China ) Contact Supplier
N,O-Bis(trimethylsilyl)acetamide
Cas No: 10416-59-8
No Data No Data Metric Ton/Day Zouping Mingxing Chemical Co.,Ltd. Contact Supplier
N,O-Bis(trimethylsilyl)acetamide -- CHemwill
Cas No: 10416-59-8
USD $ 1.0-1.0 / Metric Ton 1 Metric Ton 5 Metric Ton/Day Chemwill Asia Co., Ltd. Contact Supplier
Top purity N,O-Bis-(Trimethylsilyl) Acetamide (BSA) with high quality and best price cas:10416-59-8
Cas No: 10416-59-8
USD $ 50.0-150.0 / Kilogram 1 Kilogram 99999 Kilogram/Year Hangzhou Dingyan Chem Co., Ltd Contact Supplier
High quality Ht--406 Bis(Trimethylsilyl)Acetamide (Bsa) supplier in China
Cas No: 10416-59-8
No Data 1 Metric Ton 30 Metric Ton/Month Simagchem Corporation Contact Supplier
N,O-Bis(trimethylsilyl)acetamide (BSA)
Cas No: 10416-59-8
USD $ 12.0-12.0 / Gram 100 Gram 1000 Metric Ton/Year Jinan Finer Chemical Co., Ltd Contact Supplier
BSA [=N,O-Bis(triMethylsilyl)acetaMide] [for Gas ChroMatography]
Cas No: 10416-59-8
No Data 1 Gram 1 Metric Ton/Week Henan Allgreen Chemical Co.,Ltd Contact Supplier
Factory Supply Trimethylsilyl N-trimethylsilylacetamidate
Cas No: 10416-59-8
No Data 1 1 Ality Chemical Corporation Contact Supplier

10416-59-8 Usage

Uses

Used for blocking and protection of hydroxyl groups in natural products, e.g. amino acids, carbohydrates; Used for blocking and protection of functional groups in organic intermediates; Used for formation of derivatives of H-acid compounds for analysis; The silylated derivatives are volatile and can therefore be determined by gas chromatography. Deblocking is preferably carried out by means of hydrolysis, giving high yields. In some cases, thermal elimination of the trimethylsilyl group is possible.

Uses

N,O-bis(trimethylsilyl)-acetamide (BSA) is frequently used with TMCS as a catalyst to modify a variety of functional groups including carboxyl groups. In one novel application, BSA was used to measure carboxypeptidase activity by forming derivatives which could be determined by gas chromatography.BSA has been used to prepare derivatives of steroids and glucocorticoids.

Uses

Powerful silylation reagent for a wide range of functional groups under mild conditions

Description

Clear to yellowish clear liquid liquid which is soluble in many nonpolar and polar aprotic solvents. The trimethylsilyl group is a frequently utilized monofunctional blocking group for protic organic and inorganic materials. As it eliminated during the silylation is neutral acetamide, N,O-Bis(trimethylsilyl)acetamide can be preferably used for substrates which are acid- or base-sensitive. N,O-bis(trimethylsilyl)-acetamide is an effective silylating agent. It is used in the pharmaceutical and in the chemical industry. Typically the silylating reaction with BSA results in neutral by-products only.

Purification Methods

Fractionate it through a spinning band column and collect liquid b 71-73o/35mm, and not higher because the main impurity MeCONHSiMe3 distils at b 105-107o/35mm. It is used for derivatising alcohols and sugars [Klebe et al. J Am Chem Soc 88 3390 1966, see Matsuo et al. Carbohydr Res 241 209 1993, Johnson Carbohydr Res 237 313 1992]. Itis FLAMMABLE and TOXIC.
InChI:InChI:1S/C8H21NOSi2/c1-8(9-11(2,3)4)10-12(5,6)7/h1-7H3/b9-8+

10416-59-8 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
TCI America (B0511)  N,O-Bis(trimethylsilyl)acetamide  >80.0%(GC) 10416-59-8 10mL 150.00CNY Detail
TCI America (B0511)  N,O-Bis(trimethylsilyl)acetamide  >80.0%(GC) 10416-59-8 100mL 650.00CNY Detail
Alfa Aesar (L00183)  N,O-Bis(trimethylsilyl)acetamide, 95%    10416-59-8 5g 141.0CNY Detail
Alfa Aesar (L00183)  N,O-Bis(trimethylsilyl)acetamide, 95%    10416-59-8 25g 280.0CNY Detail
Alfa Aesar (L00183)  N,O-Bis(trimethylsilyl)acetamide, 95%    10416-59-8 100g 817.0CNY Detail
Alfa Aesar (L00183)  N,O-Bis(trimethylsilyl)acetamide, 95%    10416-59-8 5g 141.0CNY Detail
Alfa Aesar (L00183)  N,O-Bis(trimethylsilyl)acetamide, 95%    10416-59-8 25g 280.0CNY Detail
Alfa Aesar (L00183)  N,O-Bis(trimethylsilyl)acetamide, 95%    10416-59-8 100g 817.0CNY Detail
Sigma-Aldrich (15269)  N,O-Bis(trimethylsilyl)acetamide  for GC derivatization 10416-59-8 15269-5ML 396.63CNY Detail
Sigma-Aldrich (15269)  N,O-Bis(trimethylsilyl)acetamide  for GC derivatization 10416-59-8 15269-10X1ML 1,171.17CNY Detail
Sigma-Aldrich (15269)  N,O-Bis(trimethylsilyl)acetamide  for GC derivatization 10416-59-8 15269-25ML 1,590.03CNY Detail
Aldrich (394831)  N,O-Bis(trimethylsilyl)acetamide  for GC derivatization 10416-59-8 394831-10X1ML 1,170.00CNY Detail

10416-59-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name N,O-Bis(trimethylsilyl)acetamide

1.2 Other means of identification

Product number -
Other names tms-ba kit

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:10416-59-8 SDS

10416-59-8Synthetic route

1-(Trimethylsilyl)imidazole
18156-74-6

1-(Trimethylsilyl)imidazole

N-Trimethylsilylacetamide
13435-12-6

N-Trimethylsilylacetamide

N,O-bis-(trimethylsilyl)-acetamide
10416-59-8

N,O-bis-(trimethylsilyl)-acetamide

Conditions
ConditionsYield
at 175℃; under 75.0075 - 146.265 Torr; 30-theoretical-plates distillation column of Old-ershaw type;79.3%
at 150 - 180℃; under 78.7579 - 150.015 Torr; 20-theoretical-plates distillation column of Old-ershaw type;198.6 g
at 100 - 121℃; under 11.2511 Torr; 30-theoretical-plates distillation column of Old-ershaw type;118.9 g
at 130 - 162℃; under 75.0075 Torr; 20-theoretical-plates distillation column of Old-ershaw type;154.2 g
at 175℃; under 71.2571 - 150.015 Torr; 20-theoretical-plates distillation column of Old-ershaw type;
acetamide
60-35-5

acetamide

chloro-trimethyl-silane
75-77-4

chloro-trimethyl-silane

N,O-bis-(trimethylsilyl)-acetamide
10416-59-8

N,O-bis-(trimethylsilyl)-acetamide

O,O-diethyl S-(trimethylsilyl) phosphorodithioate
18306-95-1

O,O-diethyl S-(trimethylsilyl) phosphorodithioate

N-sulphinylacetamide
16767-75-2

N-sulphinylacetamide

A

bis(diethoxyphosphoryl)disulphide
2901-90-8

bis(diethoxyphosphoryl)disulphide

B

N,O-bis-(trimethylsilyl)-acetamide
10416-59-8

N,O-bis-(trimethylsilyl)-acetamide

C

bis(diethoxyphosphinothioyl)trisulfide
6926-73-4

bis(diethoxyphosphinothioyl)trisulfide

D

Hexamethyldisiloxane
107-46-0

Hexamethyldisiloxane

Conditions
ConditionsYield
for 24h; Ambient temperature; sealed tube;A 2.3 g
B 1.1 g
C 2.1 g
D 1.4 g
O,O-diethyl S-(trimethylsilyl) phosphorodithioate
18306-95-1

O,O-diethyl S-(trimethylsilyl) phosphorodithioate

N-sulphinylacetamide
16767-75-2

N-sulphinylacetamide

A

bis(diethoxyphosphoryl)disulphide
2901-90-8

bis(diethoxyphosphoryl)disulphide

B

N,O-bis-(trimethylsilyl)-acetamide
10416-59-8

N,O-bis-(trimethylsilyl)-acetamide

C

Hexamethyldisiloxane
107-46-0

Hexamethyldisiloxane

D

1,1,1-trimethyl-N-phenyl-N-(trimethylsilyl)-silanamine
4147-89-1

1,1,1-trimethyl-N-phenyl-N-(trimethylsilyl)-silanamine

Conditions
ConditionsYield
for 24h; Ambient temperature; sealed tube;A 2.3 g
B 1.1 g
C 1.4 g
D 2.1 g
N-sulphinylacetamide
16767-75-2

N-sulphinylacetamide

phenylthiotrimethylsilane
4551-15-9

phenylthiotrimethylsilane

A

N,O-bis-(trimethylsilyl)-acetamide
10416-59-8

N,O-bis-(trimethylsilyl)-acetamide

B

Hexamethyldisiloxane
107-46-0

Hexamethyldisiloxane

C

diphenyldisulfane
882-33-7

diphenyldisulfane

Conditions
ConditionsYield
for 24h; Ambient temperature;A 1.6 g
B 1.3 g
C 1.7 g
acetamide
60-35-5

acetamide

1-(Trimethylsilyl)imidazole
18156-74-6

1-(Trimethylsilyl)imidazole

N,O-bis-(trimethylsilyl)-acetamide
10416-59-8

N,O-bis-(trimethylsilyl)-acetamide

Conditions
ConditionsYield
at 165℃; under 112.511 - 150.015 Torr; 20-theoretical-plates distillation column of Old-ershaw type;155.7 g
at 140 - 166℃; under 75.0075 Torr; 20-theoretical-plates distillation column of Old-ershaw type;
at 163 - 180℃; under 75.0075 - 150.015 Torr; 20-theoretical-plates distillation column of Old-ershaw type;167.6 g
at 175℃; under 78.7579 - 150.015 Torr; 20-theoretical-plates distillation column of Old-ershaw type;199.5 g
N,O-bis-(trimethylsilyl)-acetamide
10416-59-8

N,O-bis-(trimethylsilyl)-acetamide

(3R,4R)-2-Amino-4-(5-benzyloxy-pyridin-2-yl)-4-hydroxy-3-methyl-butyric acid

(3R,4R)-2-Amino-4-(5-benzyloxy-pyridin-2-yl)-4-hydroxy-3-methyl-butyric acid

(3R,4R)-2-Amino-4-(5-benzyloxy-pyridin-2-yl)-3-methyl-4-trimethylsilanyloxy-butyric acid

(3R,4R)-2-Amino-4-(5-benzyloxy-pyridin-2-yl)-3-methyl-4-trimethylsilanyloxy-butyric acid

Conditions
ConditionsYield
In methanol for 18h; Ambient temperature;100%
N,O-bis-(trimethylsilyl)-acetamide
10416-59-8

N,O-bis-(trimethylsilyl)-acetamide

N4-Boc-cytosine
172405-14-0

N4-Boc-cytosine

2-(trimethylsilyl)-N4-Boc-cytosine
528584-48-7

2-(trimethylsilyl)-N4-Boc-cytosine

Conditions
ConditionsYield
In acetonitrile at 20℃; for 2h;100%
3-cinnamyloxy-3-(3,4-methylenedioxyphenyl)-2-nitro-1-propanol
1017684-56-8

3-cinnamyloxy-3-(3,4-methylenedioxyphenyl)-2-nitro-1-propanol

N,O-bis-(trimethylsilyl)-acetamide
10416-59-8

N,O-bis-(trimethylsilyl)-acetamide

(1R*,4S*,5R*,8R*)-8-(3,4-methylenedioxyphenyl)-4-phenyl-2-(trimethylsilyloxy)-1-(trimethylsilyloxy)methyl-2-aza-3,7-dioxabicyclo[3.3.0]octane

(1R*,4S*,5R*,8R*)-8-(3,4-methylenedioxyphenyl)-4-phenyl-2-(trimethylsilyloxy)-1-(trimethylsilyloxy)methyl-2-aza-3,7-dioxabicyclo[3.3.0]octane

Conditions
ConditionsYield
With triethylamine In toluene; acetonitrile at 85℃; for 24h;100%
N,O-bis-(trimethylsilyl)-acetamide
10416-59-8

N,O-bis-(trimethylsilyl)-acetamide

triethylammonium α-L-2',3'-dideoxy-3'-thiacytadin-5'-yl phosphonate

triethylammonium α-L-2',3'-dideoxy-3'-thiacytadin-5'-yl phosphonate

C14H28N3O5PSSi2

C14H28N3O5PSSi2

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 20℃; for 0.166667h;100%
N,O-bis-(trimethylsilyl)-acetamide
10416-59-8

N,O-bis-(trimethylsilyl)-acetamide

1-cyclohexyl-1-hydroxy-1-phenylpropan-2-one
28192-98-5

1-cyclohexyl-1-hydroxy-1-phenylpropan-2-one

1-cyclohexyl-1-phenyl-1-(trimethylsiloxy)propan-2-one
119497-46-0

1-cyclohexyl-1-phenyl-1-(trimethylsiloxy)propan-2-one

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 130℃; for 12h;98.1%
N,O-bis-(trimethylsilyl)-acetamide
10416-59-8

N,O-bis-(trimethylsilyl)-acetamide

friedelin
559-74-0

friedelin

3-trimethylsiloxyfriedel-2-ene
161739-59-9

3-trimethylsiloxyfriedel-2-ene

Conditions
ConditionsYield
With N,N,N,N,N,N-hexamethylphosphoric triamide; sodium at 20℃; for 1h;98.1%
TREHALOSE
99-20-7

TREHALOSE

N,O-bis-(trimethylsilyl)-acetamide
10416-59-8

N,O-bis-(trimethylsilyl)-acetamide

2,3,4,6,2',3',4',6'-octa-O-trimethylsilyl-α,α-D-trehalose
42390-78-3

2,3,4,6,2',3',4',6'-octa-O-trimethylsilyl-α,α-D-trehalose

Conditions
ConditionsYield
With tetrabutyl ammonium fluoride In tetrahydrofuran Ambient temperature;98%
With tetrabutyl ammonium fluoride In N,N-dimethyl-formamide at 15 - 20℃; for 0.75h;
With tetrabutyl ammonium fluoride In N,N-dimethyl-formamide at 0℃; for 2h; Inert atmosphere;
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