1041693-72-4Relevant academic research and scientific papers
[1,2]-Aryl migration in the synthesis of substituted indoles: scope, mechanism, and high throughput experimentation
Pei, Tao,Tellers, David M.,Streckfuss, Eric C.,Chen, Cheng-yi,Davies, Ian W.
experimental part, p. 3285 - 3291 (2009/08/08)
A mild regioselective synthesis of substituted indoles from readily accessible 1-(2-aminophenyl)-2-chloroethanones is described. Addition of a range of carbon nucleophiles to α-chloro acetophenones 1 generates 2-substituted indoles 2 in moderate to excell
Expanding the [1,2]-aryl migration to the synthesis of substituted indoles
Pei, Tao,Chen, Cheng-Yi,Dormer, Peter G.,Davies, Ian W.
, p. 4231 - 4233 (2008/12/23)
(Chemical Equation Presented) Closing in on the product: A range of 2- and 2,3-substituted indoles 2 have been synthesized in moderate to excellent yields by the addition of carbon nucleophiles (organometallic reagents, RM) to readily accessible 1-(2-aminophenyl)-2-chloroethanones of type 1 under mild conditions (see scheme). A mechanism has been proposed that involves a unique [1,2]-aryl migration of intermediate 3.
