104180-85-0Relevant academic research and scientific papers
Concise total synthesis of (+)-brefeldin a: A combined β-lactone/ cross-metathesis-based strategy
Wang, Yingcai,Romo, Daniel
, p. 3231 - 3234 (2007/10/03)
equation presented A highly convergent total synthesis of (+)-brefeldin A that relies on a diastereoselective, β-lactone-based cyclopentane synthesis combined with complex cross-metathesis reactions is described. The utility of β-lactones for natural product synthesis and the versatility of cross-metathesis in this context were demonstrated, including the tolerance of an epimerizable aldehyde and a β-lactone.
