1041849-75-5Relevant academic research and scientific papers
The design, synthesis, and evaluation of C7 diversified bryostatin analogs reveals a hot spot for PKC affinity
Wender, Paul A.,Verma, Vishal A.
supporting information; experimental part, p. 3331 - 3334 (2009/05/11)
(Chemical Equation Presented) The first series of systematically varied C7-functionalized bryostatin analogs (12 members in all) have been synthesized through an efficient and convergent route. A new hotspot for PKC affinity, not present in the natural products, has been discovered, allowing for affinity control and potentially for selective regulation of PKC isozymes. Several analogs exhibit single-digit nanomolar affinity to PKC and display superior activity compared to bryostatin against the leukemia cell line K562.
