1041857-66-2Relevant academic research and scientific papers
Synthesis and DNA cleaving activity of water-soluble non-conjugated thienyl tetraynes
Torikai, Kohei,Otsuka, Yoichi,Nishimura, Makoto,Sumida, Megumi,Kawai, Tomoji,Sekiguchi, Kiyotoshi,Ueda, Ikuo
, p. 5441 - 5451 (2008/12/21)
Water-soluble non-conjugated thienyl tetraynes (3-6) were synthesized and their DNA cleaving activity was evaluated using electrophoresis, atomic force microscopy (AFM) and Escherichia coli (E. coli) transformation techniques. The amino-functionalized compound 4 was shown to possess an activity to cleave plasmid DNA by both electrophoresis and E. coli transformation techniques. AFM also showed a cleavage of the circular DNA into a linear form with a formation of burst-star-shaped architectures, which were envisaged to be cross-linked DNA oligomers.
