1041860-72-3Relevant academic research and scientific papers
NOVEL VIRAL REPLICATION INHIBITORS
-
Page/Page column 31, (2009/03/07)
The present invention relates to novel compounds and to their use as a medicament, more in particular for the treatment or prevention of viral infections in mammals. The invention also relates to processes for the preparation of compounds according to the
Arylethynyltriazole acyclonucleosides inhibit hepatitis C virus replication
Zhu, Ruizhi,Wang, Menghua,Xia, Yi,Qu, Fanqi,Neyts, Johan,Peng, Ling
experimental part, p. 3321 - 3327 (2009/04/11)
Novel acyclic triazole nucleosides with various ethynyl moieties appended on the triazole nucleobase were synthesized efficiently using a convenient one-step Sonogashira reaction in aqueous solution and under microwave irradiation. One of the compounds, 1f, inhibited HCV subgenomic replication with a 50% effective concentration (EC50) of 22 μg/ml and did not inhibit proliferation of the host cell at a concentration of 50 μg/ml. A preliminary SAR study suggests that the appended phenyl ring as well as the rigid triple bond linker contributes importantly to the anti-HCV activity.
