1041860-75-6Relevant academic research and scientific papers
Arylethynyltriazole acyclonucleosides inhibit hepatitis C virus replication
Zhu, Ruizhi,Wang, Menghua,Xia, Yi,Qu, Fanqi,Neyts, Johan,Peng, Ling
experimental part, p. 3321 - 3327 (2009/04/11)
Novel acyclic triazole nucleosides with various ethynyl moieties appended on the triazole nucleobase were synthesized efficiently using a convenient one-step Sonogashira reaction in aqueous solution and under microwave irradiation. One of the compounds, 1f, inhibited HCV subgenomic replication with a 50% effective concentration (EC50) of 22 μg/ml and did not inhibit proliferation of the host cell at a concentration of 50 μg/ml. A preliminary SAR study suggests that the appended phenyl ring as well as the rigid triple bond linker contributes importantly to the anti-HCV activity.
