104196-91-0Relevant academic research and scientific papers
Functionalization of the Methyl Group of 2-Methylindole by Direct Generation of a C,N-Dianion
Inagaki, Satoshi,Nishizawa, Yoshihiro,Sugiura, Takashi,Ishihara, Hideharu
, p. 179 - 180 (2007/10/02)
The first method for directly generating C,N-dianion from an alkyl-substituted ?-excessive N-heterocyclic compound (2-methylindole) has been developed.It involves treatment with 3 equiv. of BuLi and 2 equiv. of ButOK in a particular sequence and results in the functionalization of the 2-methyl group of the indole in a regiospecific manner.
