104202-48-4Relevant academic research and scientific papers
Selective Claisen rearrangement and iodination for the synthesis of polyoxygenated allyl phenol derivatives
Bochicchio, Antonella,Cefola, Rossella,Choppin, Sabine,Colobert, Fran?oise,Di Noia, Maria Antonietta,Funicello, Maria,Hanquet, Gilles,Pisano, Isabella,Todisco, Simona,Chiummiento, Lucia
, p. 4053 - 4055 (2016/08/18)
Allyl aryl ethers and allyl phenol derivatives were prepared starting from commercial or synthetized phenols. Either Williamson reaction or Et2AlCl catalyzed Claisen rearrangement was performed to obtain the polyoxygenated molecules. The pivotal allyl phenols were then modified by methylation, iodocyclization or electrophilic aromatic iodination to afford the polyoxygenated derivatives in good to excellent yields. Additionally, their antibacterial properties were also investigated against Gram-positive and Gram-negative bacteria.
An Improved Synthesis of 1,4-Benzo- and 1,4-Naphthoquinones Bearing Active Substituents
Syper, Ludwik,Kloc, Krystian,Mlochowski, Jacek
, p. 808 - 822 (2007/10/02)
The synthesis of 1,4-benzoquinones and 1,4-naphthoquinones 3a-j carrying substituents such as methoxyl, allyl or oxiranyl was substantially improved.The 1-methoxy-4-methoxymethyloxy 2a-d, g-k or 1,4-bis(methoxymethyloxy) derivatives 2e-f were used, as a substrates instead of 1,4-dimethoxy derivatives 1a-j hitherto used and they were oxidized with silver(II) dipicolinate.Among numerous examples, the synthesis of a new analog of ubiquinone 3d with the oxiranyl substituent, being a new bioactivated alkylating agent, is reported.
