1042093-16-2Relevant articles and documents
Simple procedure for the synthesis of 5,7-diarylpyrido[2,3-d]pyrimidine derivatives catalyzed by KF-alumina
Wang, Xiang-Shan,Zhang, Mei-Mei,Li, Qing,Yao, Chang-Sheng,Tu, Shu-Jiang
, p. 1896 - 1908 (2008/09/20)
A simple KF/Al2O3-catalyzed reaction of 1,3-diaryl-2-propen-1-one and 2,6-diamino-4-hydroxylpyrimidine in ethyl alcohol gave aromatized 5,7-diarylpyrido[2,3-d]pyrimidine derivative by air oxidation. On the other hand, the unaromatized intermediate products were isolated under dry nitrogen successfully. A possible reaction mechanism with two pathways to lose water was proposed based on the further experimental results; one of them was confirmed by 1H NMR spectra of isolated intermediate product. Copyright Taylor & Francis Group, LLC.