1042093-41-3Relevant academic research and scientific papers
A general strategy for construction of both 2,6-cis- and 2,6-trans-disubstituted tetrahydropyrans: Substrate-controlled asymmetric total synthesis of (+)-scanlonenyne
Lee, Hyunjoo,Kim, Kwan Woo,Park, Janghyun,Kim, Hyoungsu,Kim, Sanghee,Kim, Deukjoon,Hu, Xiangqian,Yang, Weitao,Hong, Jiyong
body text, p. 4200 - 4203 (2009/03/12)
(Chemical Equation Presented) A synthetic three-ring circus: The asymmetric total synthesis of (+)-scanlonenyne includes a sequential epimerization and intramolecular hetero-Michael addition for the construction of pyrano-γ-lactones (see scheme; DBU: 1,8-diazabicyclo[5.4.0]undec-7-ene), a highly efficient one-carbon homologation/bromination strategy, and a Weinreb ketone synthesis/cross-metathesis protocol for the elaboration of a sensitive side chain.
Catalytic enantioselective aldol-type reaction of β-ketosters with acetals
Umebayashi, Natsuko,Hamashima, Yoshitaka,Hashizume, Daisuke,Sodeoka, Mikiko
supporting information; experimental part, p. 4196 - 4199 (2009/03/12)
(Chemical Equation Presented) Two activations, one catalyst: By using cationic Pd and Pt complexes, a catalytic enantioselective aldol-type reaction of β-ketoesters with acetals has been developed (see scheme). The formation of metal enolates occurs under acidic conditions to allow the use of acetals as electrophiles to give the desired aldol products in high diastereoseletivity and enantioselectivity.
