1042093-91-3Relevant academic research and scientific papers
A general strategy for construction of both 2,6-cis- and 2,6-trans-disubstituted tetrahydropyrans: Substrate-controlled asymmetric total synthesis of (+)-scanlonenyne
Lee, Hyunjoo,Kim, Kwan Woo,Park, Janghyun,Kim, Hyoungsu,Kim, Sanghee,Kim, Deukjoon,Hu, Xiangqian,Yang, Weitao,Hong, Jiyong
supporting information; experimental part, p. 4200 - 4203 (2009/03/12)
(Chemical Equation Presented) A synthetic three-ring circus: The asymmetric total synthesis of (+)-scanlonenyne includes a sequential epimerization and intramolecular hetero-Michael addition for the construction of pyrano-γ-lactones (see scheme; DBU: 1,8-diazabicyclo[5.4.0]undec-7-ene), a highly efficient one-carbon homologation/bromination strategy, and a Weinreb ketone synthesis/cross-metathesis protocol for the elaboration of a sensitive side chain.
