1042105-86-1Relevant academic research and scientific papers
Discovery of potent and selective dipeptidyl peptidase IV inhibitors derived from β-aminoamides bearing subsituted triazolopiperazines
Kim, Dooseop,Kowalchick, Jennifer E.,Brockunier, Linda L.,Parmee, Emma R.,Eiermann, George J.,Fisher, Michael H.,He, Huaibing,Leiting, Barbara,Lyons, Kathryn,Scapin, Giovanna,Patel, Sangita B.,Petrov, Aleksandr,Pryor, Kelly Ann D.,Roy, Ranabir Sinha,Wu, Joseph K.,Zhang, Xiaoping,Wyvratt, Matthew J.,Zhang, Bei B.,Zhu, Lan,Thornberry, Nancy A.,Weber, Ann E.
, p. 589 - 602 (2008/09/17)
A series of β-aminoamides bearing triazolopiperazines have been discovered as potent, selective, and orally active dipeptidyl peptidase IV (DPP-4) inhibitors by extensive structure-activity relationship (SAR) studies around the triazolopiperazine moiety.
BETA-AMINO HETEROCYCLIC DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES
-
Page/Page column 53, (2010/02/07)
The present invention is directed to compounds which are inhibitors of the dipeptidyl peptidase-IV enzyme ("DP-IV inhibitors") and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
