104211-03-2

Upstream product

• 35572-31-7 (4R,5R)-2-Phenyl-1,3-dioxolan-4,5-dicarbonsaeure-diethylester 
• 104333-85-9 O-benzylidene tartrate 
• 119770-87-5 (2R,3R)-diethyl 2-(benzyloxy)-3-hydroxysuccinate 

Downstream Products

• 104211-11-2 Ethyl[2R-(R*,R*)]-2[(4-methylphenylsulfonyl)-oxy]-4-oxo-3-(benzyloxy)-4-[(benzyloxy)-amino]-butanoate 
• 104211-13-4 ethyl(2S-trans)-1,3-bis-(benzyloxy)-4-oxo-2-azetidine-carboxylate 
• 104211-05-4 ethyl[2R-(R*,R*)]-2-hydroxy-4-oxo-3-benzyloxy-4-[(benzyloxy)-amino]-butanoate 
• 104211-07-6 (2R,3R)-2,N-Bis-benzyloxy-3-hydroxy-succinamic acid ethyl ester 
• 104211-09-8 (2R,3R)-2,N¹,N⁴-Tris-benzyloxy-3-hydroxy-succinamide 

Relevant academic research and scientific papers

Synthesis of 3α-alkoxy-4β-substituted-2-azetidinones from L(+)-tartaric acid

Tartaric acid, regioselective saponification, Pig Liver Esterase, 3-methoxy-2-azetidinone, N-Hydroxy-2-thiopyridone, radical decarboxylation. The synthesis of 3α-alkoxy-4β-azetidinones from L(+) tartaric acid is described. Regioselective saponification and methylation along with a stereo selective radical decarboxylative alkylation are key steps leading to optically pure trans-β-lactams.

CHIRAL SYNTHESIS OF 3,4-DISUBSTITUTED 2-AZETIDINONES FROM (R,R)-(+)-TARTARIC ACID

A novel route is described for the enantioselective synthesis of 2-azetidinones 24 and 25 from (R,R)-(+)-tartaric acid.Monomethylation, monobenzylation of 2 and the use of site specific pig liver esterase (PLE) to produce 6 and 7 are the key steps in sequ