1042129-03-2Relevant academic research and scientific papers
Converting sequences of aromatic amino acid monomers into functional three-dimensional structures: Second-generation helical capsules
Bao, Chunyan,Kauffmann, Brice,Gan, Quan,Srinivas, Kolupula,Jiang, Hua,Huc, Ivan
, p. 4153 - 4156 (2008)
New codes for sequence-structure-function relationships can be elaborated in aromatic oligoamide foldamers upon varying main-chain components. Each monomer carries its own structural and functional features and enables oligomeric sequences to be designed
A highly stable double helix of aromatic oligoamide comprised of fused ring aromatic units
Gan, Quan,Shang, Jie,Kauffmann, Brice,Wang, Ying,Bie, Fusheng,Jiang, Hua
scheme or table, p. 4479 - 4484 (2012/07/27)
Aromatic oligoamides of 2,6-diaminofluorobenzene and 1,8- diazafluoroanthrancene-2,7-diacid have been synthesized by a convergent method. The heptameric oligoamide can not only fold into a single helix but also hybridize into a highly stable double helix through intensive intermolecular aromatic stackings, which has been extensively characterized in the solid state by single crystal X-ray diffractions and in solution by 1H NMR, NOESY, and UV/vis spectra. The Kdim values of the heptamer are over 107 L mol-1 in various solutions at rt. The extensive interstrand interactions, enlarged diameter (5.4 ?), and lower torsion angles (13°) render heptamer 1 readily to hybridize into a highly stable double helix based on spring-like extension mechanism.
