1042129-34-9

Upstream product

• 3934-20-1 2,6-Dichloropyrimidine 
• 1193-02-8 4-aminotiophenol 

Downstream Products

• 1207681-67-1 2-(4-(4-aminophenylthio)pyrimidin-2-ylamino)ethanol 
• 1207681-68-2 tert-butyl 2-(4-(4-aminophenylthio)pyrimidin-2-ylamino)ethyl(methyl)carbamate 
• 1207681-75-1 4-(2-(1H-indol-2-yl)pyrimidin-4-ylthio)aniline 

Relevant academic research and scientific papers

AURORA KINASE MODULATORS AND METHODS OF USE

The present invention relates to chemical compounds having a general formula I (I) wherein A1-6, L1, R1, R4-6 and n are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of such kinase proteins. For example, the compounds are capable of modulating Aurora kinase thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds and methods of treating disease states related to the activity of Aurora kinase.

THIOPYRIMIDINE-BASED COMPOUNDS AND USES THEREOF

The present invention relates to thiopyrimidine-based compounds that are inhibitors of protein kinases including JAK kinases. In particular, the compounds are selective for JAK1, JAK2 or JAK3 kinases and combinations thereof such as JAK1 and JAK2. The kinase inhibitors can be used in the treatment of kinase associated diseases such as immunological and inflammatory diseases including organ transplants; hyperproliferative diseases including cancer and myeloproliferative diseases; viral diseases; metabolic diseases and vascular diseases.