1042149-13-2Relevant academic research and scientific papers
Direct palladium-catalyzed C-4 arylation of tri-substituted furans with aryl chlorides: An efficient access to heteroaromatics
Yang, Hai,Zheng, Zhishuo,Zeng, Jian,Liu, Huajie,Yi, Bing
, p. 2623 - 2626 (2012/10/29)
A series of functionalized furans were synthesized by way of a palladium -catalyzed coupling reaction of 2,3,5- trisubstituted furans with aryl chlorides through C-H bond cleavages at C-4 position. The feature of the reaction was facilitative preparation of furan derivatives with good functional group tolerance. All reactions gave the desired products in moderate to good yields in the presences of BuAd2P and t-BuOK in DMF at 120 °C after 15 h.
Ruthenium/TFA-catalyzed coupling of activated secondary propargylic alcohols with cyclic 1,3-diones: Furan versus pyran ring formation
Cadierno, Victorio,Diez, Josefina,Gimeno, Jose,Nebra, Noel
, p. 5852 - 5858 (2008/12/21)
(Chemical Equation Presented) A catalytic system consisting of the 16-electron allyl-ruthenium(II) complex [Ru(η3-2-C 3H4Me)(CO)(dppf)][SbF6] (dppf = 1,1′-bis(diphenylphosphino)ferrocene) and trifluoroacetic acid (TFA) has been used to promote the coupling between secondary propargylic alcohols and cyclic 1,3-diketones. The nature of the resulting products was found to be dependent on the ring size of the dicarbonyl compound employed. Thus, whereas 6,7-dihydro-5H-benzofuran-4-ones have been selectively obtained starting from 1,3-cyclohexanediones, via furan-ring formation, the use of 1,3- cyclopentanedione leads instead to 6,7-dihydro-4H-cyclopenta[b]pyran-5-ones via a pyran-ring formation process.
