104224-10-4Relevant articles and documents
PROCESS FOR IDENTIFYING RAR-RECEPTOR-ANTAGONIST COMPOUNDS
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, (2008/06/13)
The present invention relates to a process for identifying RAR-antagonist molecules, characterized in that it comprises the following steps: (i) a sufficient amount of an RAR-agonist molecule is applied topically to a part of the skin of a mammal, (ii) a molecule capable of having an RAR-antagonist activity is administered systemically or topically to this same mammal, or to this same part of the skin of the mammal, before, during or after step (i) , and (iii) the response on that part of the skin of the mammal thus treated is evaluated.