104230-87-7Relevant academic research and scientific papers
Identification and synthesis of major metabolites of Vasopressin V2-receptor agonist WAY-151932, and antagonist, Lixivaptan
Molinari, Albert J.,Trybulski, Eugene J.,Bagli, Jehan,Croce, Susan,Considine, John,Qi, Jian,Ali, Kadum,DeMaio, William,Lihotz, Lynne,Cochran, David
, p. 5796 - 5800 (2008/09/21)
Small molecule agonists and antagonists of the V2-vasopressin receptor have been discovered and have undergone clinical trials. In conjunction with these discovery programs, the synthesis and biological testing of various metabolites associated with these clinical targets were actively pursued. We now report the results of our synthetic efforts and the corresponding biological data generated for several of the metabolites of WAY-151932 and CL-347985 (Lixivaptan).
9H-pyrrolo[2,1-c]-1,2,4-triazolo[4,3-a][1,4]benzodiazepines
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, (2008/06/13)
Disclosed are the novel compounds of formula I STR1 wherein ring A is unsubstituted or substituted by one or two identical or different substituents selected from lower alkyl, halogen, trifluoromethyl, lower alkoxy, hydroxy and acyloxy; or ring A is substituted on adjacent carbon atoms by lower alkylenedioxy; R represents hydrogen, halogen or lower alkyl; and Ar represents carbocyclic aryl or heteroaryl;which are useful as benzodiazepine receptor agonists, processes for preparing the same, pharmaceutical compositions comprising said compounds and methods of treating nervous system disorders, such as anxiety and epilepsy, by administration of said compounds and pharmaceutical compositions to mammals.
