1042317-68-9

Basic information

• Product Name: C₁₆H₁₆N₂O₂
• CAS NO: 1042317-68-9
• Molecular Weight: 268.315
• Mol File: 1042317-68-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₆H₁₆N₂O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₆H₁₆N₂O₂(1042317-68-9)
• EPA Substance Registry System: C₁₆H₁₆N₂O₂(1042317-68-9)

Safety Data

• Hazardous Substances Data: 1042317-68-9(Hazardous Substances Data)

Upstream product

• 26215-14-5 7-amino-2H-1,4-benzoxazin-3(4H)-one 
• 104-87-0 4-methyl-benzaldehyde 

Relevant articles and documents

Synthesis of novel 7-benzylamino-2H-1,4-benzoxazin-3(4H)-ones as anticonvulsant agents

A series of 7-benzylamino-2H-1,4-benzoxazin-3(4H)-ones were synthesized using 2-amino-5-nitrophenol as a starting material. Their anticonvulsant activities were evaluated by the maximal electroshock test (MES test) and their neurotoxicity was evaluated by the rotarod neurotoxicity test (Tox.). The MES test showed that 7-(4-fluorobenzylamino)-2H-1,4-benzoxazin-3(4H)-one 4b was the most potent with ED50 value of 31.7 mg/kg and protective index (PI = TD50/ED50) value of 7.2. To explain the possible mechanism of anticonvulsant activity, the compound 4b was tested in sc-PTZ test, isoniazid test and strychnine test.