1042401-35-3Relevant academic research and scientific papers
A convenient synthesis and cytotoxic evaluation of N-unsubstituted α-methylene-γ-lactams
Krawczyk, Henryk,Albrecht, ?ukasz,Wojciechowski, Jakub,Wolf, Wojciech M.,Krajewska, Urszula,Rózalski, Marek
, p. 6307 - 6314 (2008)
Chemoselective reduction of 3-aryl-2-diethoxyphosphoryl-4-nitroalkanoates provided the corresponding α-diethoxyphosphoryl-γ-lactams in completely diastereoselective manner. The products were shown to be useful substrates for the synthesis of mono-β-substituted and β,γ-disubstituted α-methylene-γ-lactams. Cytotoxicity of these compounds was evaluated.
